110 Greene St. Fifth Floor Office Rental

  • 5,500 SQFT
  • Lease Term Negotiable
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Access opens into a bright, open loft environment where a wide reception and informal landing area naturally transitions into the main working portion of the space, creating an immediate sense of scale and flexibility. The layout unfolds across a large, column-dotted open area that comfortably supports a dense workstation configuration, with long benching runs and collaborative seating arrangements easily accommodated throughout the central floor. High ceilings, exposed structure, and polished flooring reinforce a classic Soho loft identity, while expansive perimeter windows spanning multiple sides of the unit pull daylight deep into the interior and create a strong visual connection to the surrounding neighborhood.

Moving along the perimeter, several enclosed rooms line the windowed edges of the space and can be utilized as private offices, executive rooms, or meeting areas depending on operational needs. These rooms benefit from direct window exposure, making them well-suited for leadership offices or client-facing conference use. Additional enclosed sections positioned closer to the core provide opportunities for internal meeting rooms, quiet focus areas, or production rooms, allowing a clear separation between collaborative and heads-down functions without disrupting the openness of the main floor.

A dedicated pantry and lounge component is integrated into the layout, offering a natural gathering point for staff and informal meetings while supporting day-to-day operations. Circulation throughout the unit is efficient and intuitive, with wide pathways that connect the open work area to perimeter rooms and shared amenities without bottlenecks. The overall configuration supports a balanced workflow, enabling simultaneous team collaboration, private discussions, and executive functions within a single cohesive floorplate.

The space is part of a larger multi-tenant floor and does not constitute a full-floor presence, yet the demised portion is substantial and well-defined, providing a strong sense of identity and operational control. Access to a shared rooftop amenity further enhances the offering, giving tenants an outdoor extension for breaks, informal gatherings, or events. Combined with the architectural character of the building and the adaptable interior layout, the unit presents an ideal opportunity for creative, technology, or media-driven companies seeking a distinctive Soho office environment that blends openness, perimeter privacy, and lifestyle-driven amenities.

Notes: Shared rooftop amenity


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110 Greene St
Building at 110 Greene St

About the Building

155-foot, 12-story residential/office building completed in 1908. Designed by William J. Dilthey and constructed for Charles Broadway Rouse, a prominent nineteenth century merchant as an annex to his main store on Broadway. The 8-bay Mercer Street facade goes through the block with a wider frontage on Greene Street. On Greene, it is clad in red brick, rusticated at the 2-story base, with rough stone pier footings and a limestone cornice across the top of the 2nd floor bearing Rouse’s name. The two main entrances, at either side, are set under segmental-arches with splayed brick headers, and have grey columns framing the doorways. The upper floors have stone sills and brick lintels, with single-window outer bays, and three middle bays of paired windows. Above a corbelled brick cornice, the top floor has a peaked parapet above both of the end bays.

On Mercer Street, the ground floor is dark-grey cast-iron, with semi-circular fanlights over the outer two bays on each side. The ground floor is capped by a broad entablature with carved garlands flanking Rouse’s name. The 2nd floor is clad in rusticated limestone, with cartouches on the outer piers, above a wreath and hanging garlands. The 3rd floor is transitional, with red brick, but also a limestone cap, extruded at the piers. From the 4th floor up, the brick of the 2nd-to-outer pier is rusticated. The 11th floor has round-arched windows in the two outer bays on each side, and a stone cornice. The top floor is crowned by a projecting black metal roof cornice, and an elaborate white iron fire escape runs down the center two bays.

The building was renovated into a multi-use residential/office/store building by Joseph Pell Lombardi. The ground floor is occupied by Mackage outerwear, and Journelle lingerie on Mercer Street, and Goldman Properties, Design Within Reach, and the Soho Building Cafe. On the Greene Street side there is an artwork embedded in the sidewalk, Subway Map Floating on a New York Sidewalk, a 1986 work by Francoise Schein. It’s a more or less accurate schematic of the subway c. 1986, but the Uptown end is pointing Downtown and vice versa.


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